A wide range of Cu(II)-catalyzed C–H activation reactions have been realized since 2006, however, whether a C–H metalation mechanism similar to Pd(II)-catalyzed C–H activation reaction is operating ...
In this study, we introduce a protocol for the methylation of the C–H bond at the C 3 position in imidazo[1,2-a]pyridine scaffolds, employing magnetic def./Cu-MOF for the activation of C(sp2)-H bonds.
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