However, the power of PROTACs lies in the engagement of E3 ligases, and currently, less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr.

Multiple E3 ubiquitin ligases and deubiquitinating enzymes ... such as tumor-associated fibroblasts (CAFs), macrophages, and the extracellular matrix (ECM). By regulating protein degradation ...