Oxidoreductases are key enzymes in biocatalysis, but their dependence on the cofactor nicotinamide adenine dinucleotide (phosphate) (NAD(P)) presents challenges due to its high consumption and ...

Nature precisely controls thousands of chemical reactions in every cell. Many of these form complex chains of reactions, analogous to a falling line of dominoes: when an enzyme triggers the first ...

Scientists describe a novel protein that spurs the post-translational modifications of the amino acid tryptophan to create an enzyme cofactor. This work may lead to the creation of new biological ...

A peptide bridge is designed to construct a fusion enzyme with electrostatic cofactor channeling, reducing NADPH input by two orders of magnitude or decreasing reaction time threefold with the same ...

Cells use flavin monooxygenases to break down foreign molecules by adding oxygen atoms to them. Biochemists have long assumed that the enzymes use a particular cofactor adduct to add the oxygen. A new ...