These innovative compounds leverage the ubiquitin-proteasome system (UPS) to degrade challenging targets, providing new avenues for intervention beyond traditional small molecules. However, the power ...

During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a small protein called ubiquitin to other proteins. This tagging, in turn, helps determine the fate of the targeted ...

In this study, we will establish the role of RING genes in fungal susceptibility using a RING gene knockout collection and Botrytis cinerea as model pathogen, through the high-throughput screening ...

E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to PCSK9 and is a potential therapeutic target. A desirable treatment target for HoFH patients is LDL-C ≤1.8 mmol/l.

Co. Ltd. has identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an androgen receptor targeting moiety through a linker acting as androgen ...

We are mainly interested in two SCF type of ubiquitin ligases (SCFSkp2 and SCFFbx4; Zeng et al. 2010). More recently we developed high throughput screening assays for identifying small molecule ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Through its E-rich motif, VGLL3 associates with KLHL15, an E3 ubiquitin ligase adapter, to prevent CtIP from proteasomal ...