Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of ...
One early study revealed the kinetic basis for E3 ligase domains within the Nup358/RanBP2 nucleoporin ... that were required for specific recognition of SUMO-PCNA in vitro and in vivo. Ongoing studies ...
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