Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene ...

DNA is the blueprint of life. Genes encode proteins and serve as the body's basic components. However, building a functioning organism also requires precise instructions about when, where, and how ...

New tech reveals findings that address long-standing theories about how bacteria begin the process of making RNA from DNA. Every living cell transcribes DNA into RNA. This process begins when an ...

To support drug discovery, a new study has revealed fundamental features of the transcription cycle in the bacteria that causes tuberculosis.

Researchers developed e2MPRA, a high-throughput technique that simultaneously measures cis-regulatory element activity and epigenetic state. By analyzing thousands of sequences, the method showed that ...

When the molecular machinery in our cells gets to work transcribing the genetic information encoded in DNA into messenger RNA (mRNA), it pauses shortly after starting. Known as promoter-proximal ...

The study, authored by Tripti Midha, Anatoly Kolomeisky and Oleg Igoshin and published in the Proceedings of the National Academy of Sciences. Every living cell must interpret its genetic code — a ...

DNA can be regarded as an extensive library that contains all genetic information. Cells do not utilize this information simultaneously. Instead, they selectively copy only the necessary segments into ...

Study in Genes & Development has shown that blocking the transcriptional regulator p300 forces tumour cells into lethal protein stress, re-sensitising chemotherapy-resistant cancers without an ...

Less than 2% of the genome codes for proteins; the rest, once called 'junk DNA', contains regulatory elements. Researchers analyzed 10,000 to reveal how variants shape gene activity.