ChIP-seq, short for chromatin immunoprecipitation sequencing, combines chromatin immunoprecipitation with real-time next generation sequencing to identify genomic binding sites that proteins such ...

The biomedical sciences have been transformed by the breakthrough of next-generation sequencing and derived techniques, such as ChIP-seq 1,2,3. Efficient use of such large-scale genomic data ...

ChIP–seq experiments generate large quantities of data, and effective computational analysis will be crucial for uncovering biological mechanisms.

ChIP-seq data analysis workflow. ChIP DNA sequencing fastq files alignment (Bowtie) reference genome index peak calling (MACS/SICER) Gene lists (NCBI) in gene, downstream, upstream, enhancer sites.

Today ChIP-Seq has enabled an even more comprehensive readout that may even include chromatin bar-coding to enable the analysis of multiple protein/DNA interaction profiles in a single reaction.