In a rat model of chronic heart failure, Xijiaqi Formula improved cardiac indices and rescued learning/memory deficits while suppressing glial activation and enhancing synaptic plasticity markers via ...

Neural activity in healthy brain releases glutamate which binds to synaptic receptors and activates Ca ++ influx and further signaling pathways of CAM/ERK/MAPK/CREB in neurons. CREB elevation leads in ...

Aurigene Oncology Ltd. has patented new proteolysis targeting chimera (PROTACs) compounds comprising a protein cereblon (CRBN)-binding moiety covalently bound to a CREB-binding protein (CREBBP; ...

The University of Michigan has identified proteolysis targeting chimeric (PROTACs) compounds comprising cereblon (CRBN) ligands covalently bonded to a CREB-binding protein (CREBBP; CBP) and/or histone ...