Bile acids, traditionally recognised for their role in lipid digestion, have emerged as key modulators of metabolic homeostasis. Recent research has explored how these endogenous molecules can ...

Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...

DEAR DR. ROACH: I’m a 67-year-old female in pretty good health. The only medications I take are for my thyroid, arthritis and hormone replacement. Early last year, I was sick with a cold/flu for a ...

Habegger is a professor in the UAB Department of Medicine Division of Endocrinology, Diabetes and Metabolism and also a scientist in the UAB Nutrition Obesity Research Center who studies how glucagon ...

Ask someone what they think of when they hear the phrase “bile acids,” and you might get a few unpleasant answers. Bile acids are linked to our full-body health, can act as drugs and are some of the ...

There are trillions of microbes in the gastrointestinal tract, and we are starting to learn more about the exact mechanisms that link those microbes and the substances they generate to changes in ...

(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...

Researchers headed by teams at the Salk Institute and at the University of California, San Diego (UCSD), have discovered, in mice, how high-fat diets (HFDs) can change gut bacteria and alter digestive ...

Bile acids are essential to digestion, by acting like a kind of detergent that breaks up fat molecules. Fat doesn't dissolve in water, but our digestive system is full of water, so the fat we consume ...

You may think of bile acids only in relation to digestion, especially after eating fatty foods, but they also play a crucial ...

In a cohort of 104 patients with intrahepatic cholestasis of pregnancy (ICP), 44% experienced recurrence in subsequent pregnancies, with peak total bile acid levels > 40 μM/L in the index pregnancy ...