Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel therapeutic target. AD, a representative form of senile dementia, occurs ...

A new study unravels the relationship between mitofusins (mitochondrial proteins) and autophagy. Using gene editing with CRISPR-Cas9, the team has been able to study these proteins without altering ...

During periods of fasting, the human body begins to consume its own damaged cells Dr Yoshinori Ohsumi: His pioneering yeast experiments revealed autophagy’s core genes and mechanisms, showing how ...

The mechanism of astrocytic autophagy plasticity plays a crucial role in AD. When the autophagy-regulating genes (LC3B and SQSTM1) in astrocytes are activated, Aβ is efficiently removed, which is ...

Illustration of an autophagosome (light blue double-membrane to the right) engulfing cellular material. David S. Goodsell and Daniel Klionsky/RCSB PDB-101, CC BY-SA Don’t let the textbook diagram of a ...