The Arizona Cardinals set a new franchise record during a loss to the San Francisco 49ers on Sunday, but not the good kind.

The Arizona Cardinals set a franchise record with 17 penalties during their latest loss, a 41-22 disaster vs. the 49ers, and it could prove costly

49ers vs Cardinals can be found only in local markets (orange) on FOX. Kevin Kugler and Daryl Johnston are on the call with Allison Williams on the sideline. You can also watch on mobile devices using NFL+ in local markets. Check your listings.

The Cardinals have now lost seven of their last eight, including two straight blowouts to divisional opponents.

If the Cardinals release Murray ahead of June 1, they would take a $57.7 million dead cap hit. If they wait until after that date, the dead money would spread across two years — $50.5 million in 2026 and $7.2 million in 2027, ESPN reported.

The Cardinals now drop to 3-7 on the season after their 41-22 Week 11 loss to the San Francisco 49ers, where they trailed from the first official snap of the game onwards. Arizona drops to 0-4 in division play. This was the second consecutive week where the Cardinals have allowed 35 points before the fourth quarter.

The NFL season continues in Week 11 when the San Francisco 49ers host the Arizona Cardinals on Sunday. Start time, how to watch, streaming and NFL schedule.

The San Francisco 49ers are expecting the return of QB Brock Purdy as they try to make a playoff push in the NFC West. They will travel to face the Arizona Cardinals on Sunday.

Key defensive stars return for the Arizona Cardinals as two were activated ahead of MNF vs the Cowboys, potentially changing the course of the game.

Kris Boyd, who played with the Cardinals in 2023 and is currently with the New York Jets, was shot early Nov 16 in Midtown Manhattan, police said.