The integrity of the genome is continuously challenged by endogenous and exogenous insults that induce DNA lesions, among which double-strand breaks (DSBs) are the most deleterious. Cells deploy a ...

"Studying that in human cells cultured at 20 percent oxygen means you're basically studying the ATM kinase under hyperactive conditions," de Lange says. "We're not saying that everybody should switch ...

New research from a team of genome scientists and DNA damage response experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments.

The ATM protein is a key signaling kinase that is activated by DNA damage and ionizing radiation. In the January 30 Nature, Christopher Bakkenist and Michael Kastan at St Jude Children's Research ...