49ers, Rams
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The game from Levi's Stadium in Santa Clara, Calif., is slated to start at 8:20 p.m. ET. The Rams are favored by 2.5-points in the latest Rams vs. 49ers odds from William Hill, while the over-under for total points scored is 51.5. Before making any 49ers vs. Rams picks, check out the NFL predictions from the SportsLine Projection Model .
The second match of this new NFL season features the San Francisco 49ers and the Los Angeles Rams on Thursday Night Football. Kickoff is set for 8:35 p.m.
Los Angeles Rams vs San Francisco 49ers picks, predictions, odds, win probabilities for NFL Week 1 Thursday Night Football game Sept. 10. Who wins?