Here are the three biggest takeaways for the Philadelphia 76ers following a road loss to the Indiana Pacers on Saturday.

Unorthodox lineups and the loss of starters due to injury have the Sixers reeling in the midst of a road trip.

Instead of Drummond or Bona, Sixers head coach Nick Nurse then opted to use Pete Nance at center. Nance hit a three on his first touch and the Sixers rather improbably made a 10-0 run. A Council slam trimmed the Pacers’ advantage to 106-100.

As we hit the halfway point in the regular season, the Philadelphia 76ers are still going through their fair share of injury woes. They'll kick off a three-game

Here is the official status of Philadelphia 76ers forwards Paul George and Guerschon Yabusele against the Indiana Pacers on Saturday.

Paul George and Guerschon Yabusele will miss the 76ers’ matchup at the Indiana Pacers on Saturday night, after both players entered the game listed as questionable with left groin tightness and right knee swelling,

INDIANAPOLIS -- The Philadelphia 76ers have had to battle through most of the season without their superstar big man, Joel Embiid, and it has caused them to fall short in a season filled with high expectations.

Joel Embiid again has swelling in his left knee and will miss the Philadelphia 76ers’ upcoming road trip, the latest injury setback for the All-Star center who has played in only 13 games this season.

Joel Embiid has only played 13 out of a possible 39 games thus far and that number isn't going to increase for at least another 7-to-10 days as the Sixers will re-evaluate him then amid his knee troubles.